Serum Creatinine is a "signal lamp" that reflects renal function. Increasing serum creatinine indicates that renal filtration function continues to decline. On the contrary, if serum creatinine is at a relatively stable level for a long time, it reflects that renal function has been relatively stable. Following this article to get answer, or you can consult ONLINE DOCTOR directly in free.
Serum creatinine is also one of the important indicators of uremia, so it has attracted much attention in the treatment process. In fact, the increase of creatinine represents the level of toxins in patients, and the accumulation of toxins will not only aggravate kidney inflammation, but also be detrimental to the recovery of renal function, and then increase the risk of uremia.
Factors that may cause a sudden rise in creatinine:
Infection is a high incidence in the treatment of nephropathy. Frequent infection can reduce the immunity of patients, aggravate inflammation, accelerate the process of renal cell fibrosis, and lead to the accumulation of creatinine and other toxins.
Every patient in different periods should pay attention to the prevention of infection. On the one hand, attention should be paid to the intake of nutrition in life, so as to avoid the low immunity caused by malnutrition and increase the risk of infection. On the other hand, attention should be paid to drug application when necessary, such as the injection of immunoglobulin, the early injection of influenza vaccine for patients with poor resistance and susceptible to colds.
Drug damage to the kidney is mainly divided into two categories. One is the abuse of drugs with clear nephrotoxicity, which accelerates the damage of renal function, and then leads to the accumulation of toxins, creatinine rise. The two drugs have no nephrotoxicity, but they have side effects of increasing creatinine. Large doses of drugs cause a sudden increase in creatinine accumulation and threaten the kidney.
During the treatment of nephropathy, some nephrotoxic drugs such as antibiotics, antipyretic and analgesic cold drugs, some Chinese herbal medicines containing aristolochic acid, and immunosuppressive agents such as tacrolimus and cyclosporine are often contacted. In the course of using these drugs, we must strictly abide by the doctor’s orders and must not abuse them in large quantities.
Some drugs that increase serum creatinine, such as proton pump inhibitors such as omeprazole and rabeprazole, angiotensin converting enzyme inhibitors (ACEI) are abbreviated as primaries such as captopril and enalapril, and angiotensin II receptor blockers (ARB) are abbreviated as antihypertensive drugs. They also have the functions of reducing protein and delaying renal function, such as normal. Losartan, valsartan, etc. In general, taking these drugs to detect creatinine elevation is not more than 20% of the current acceptable, once more than 20% should pay attention to the dosage problem.
At different stages of nephropathy, different symptoms or serious complications may occur, and the degree of impact on the progress of renal function varies. Hypertension, for example, usually begins at the stage of renal insufficiency and becomes one of the symptoms of accelerated renal failure. In addition, severe anemia, hyperkalemia and other factors will accelerate the destruction of the kidney.
To prevent and cure these complications, on the one hand, we should pay attention to taking medicine and timely treatment. For example, hypertension should be treated with antihypertensive drugs, and other antihypertensive and anti-inflammatory drugs should be used reasonably to reduce the risk of renal failure. On the other hand, we should pay attention to monitoring the indicators of hypertension, blood potassium, blood phosphorus and hemoglobin so as to timely understand the blood flow and electrolytes in the kidney so as to prevent the condition of the disease. Deterioration also helps to stabilize creatinine.
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